Columbia researchers bioprint seamless 3D skin grafts for burn patients

The science of grafting skin has come a long way from the days of scraping it off one part of a patient’s body and slapping it back on somewhere else to cover a nasty burn or injury. These days grafts are commonly bioprinted like living inkjets using the patient’s cultured cells to seed the growing process, down to the vascularization. The primary shortcoming of these printed grafts is that they can only be produced in flat sheets with open edges. This method “disregard[s] the fully enclosed geometry of human skin,” argue a team of researchers from Columbia University. Instead, they’ve devised a novel means of producing skin in virtually any complex 3D shape they need — from ears and elbows to entire hands printed like a pair of Buffalo Bill’s mittens. 

The team published their findings, “Engineering edgeless human skin with enhanced biomechanical properties,” in the January issue of Scientific Advances. They explained how they engineered, “the skin as a fully enclosed 3D tissue that can be shaped after a body part and seamlessly transplanted as a biological clothing.”

“Three-dimensional skin constructs that can be …read more